The biggest game of the NFL season is taking place in Orchard Park on Sunday, as the Kansas City Chiefs head up to Highmark Stadium to take on the Buffalo Bills (4:25 p.m. ET on CBS) in a battle of the top two teams in the AFC.

The Kansas City Chiefs face their toughest test of the season as Patrick Mahomes heads to New York to face Josh Allen and the Buffalo Bills at the Highmark Stadium on Sunday, Septe

Chiefs vs. Bills may be the game of the week. Mahomes and Josh Allen have faced off a total of seven times, with Mahomes winning four of those matchups. However, it's Allen who ha

Josh Allen vs. Patrick Mahomes, playoff games and exciting regular seasons games have made this a premier game on the NFL schedule.

ESPN believes that Buffalo Bills wide receiver Khalil Shakir could be in for a big game when his team hosts the Kansas City Chiefs in Week 11.

The Buffalo Bills will take a five-game winning streak into their Week 11 showdown with the undefeated Kansas City Chiefs. They will leave with it intact.

Most NFL fans are under the belief that the Kansas City Chiefs have dominated the Buffalo Bills in recent years. However, the Bills have held their own, winning 3 of the last 6 meetings between the two teams.